Advancing paternal age and psychiatric disorders.
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چکیده
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منابع مشابه
Paternal age at childbearing and offspring psychiatric and academic morbidity.
IMPORTANCE Advancing paternal age is associated with increased genetic mutations during spermatogenesis, which research suggests may cause psychiatric morbidity in the offspring. The effects of advancing paternal age at childbearing on offspring morbidity remain unclear, however, because of inconsistent epidemiologic findings and the inability of previous studies to rigorously rule out confound...
متن کاملAdvancing paternal age and the risk of schizophrenia.
BACKGROUND A major source of new mutations in humans is the male germ line, with mutation rates monotonically increasing as father's age at conception advances, possibly because of accumulating replication errors in spermatogonial cell lines. METHOD We investigated whether the risk of schizophrenia was associated with advancing paternal age in a population-based birth cohort of 87 907 individ...
متن کاملDifferences in maternal and paternal age between schizophrenia and other psychiatric disorders.
Advanced parental age has been shown to increase offspring risk for a number of neuropsychiatric disorders including schizophrenia and Down's syndrome. Other psychiatric disorders have been less studied with respect to the effect of parental age on offspring risk. In this study we examine if advanced parental age increased risk for ICD-10 diagnoses. We hypothesized that advanced parental age wo...
متن کاملAdvanced paternal age increases risk of bipolar disorder in offspring.
ED FROM Frans EM, Sandin S, Reichenberg A, et al. Advancing paternal age and bipolar disorder. Arch Gen Psychiatry 2008;65:1034–40. Correspondence to: Emma M Frans, MMedSc, Department of Medical Epidemiology and Biostatistics, Karolinksa Institute, PO Box 281, SE-171 77 Stockholm, Sweden; [email protected] Source of funding: None reported. c A table is published online only at http://ebmh.bmj.co...
متن کاملAdvancing Paternal Age Is Associated with Deficits in Social and Exploratory Behaviors in the Offspring: A Mouse Model
BACKGROUND Accumulating evidence from epidemiological research has demonstrated an association between advanced paternal age and risk for several psychiatric disorders including autism, schizophrenia and early-onset bipolar disorder. In order to establish causality, this study used an animal model to investigate the effects of advanced paternal age on behavioural deficits in the offspring. ME...
متن کاملAutism risk across generations: a population-based study of advancing grandpaternal and paternal age.
IMPORTANCE Advancing paternal age has been linked to autism. OBJECTIVE To further expand knowledge about the association between paternal age and autism by studying the effect of grandfathers' age on childhood autism. DESIGN Population-based, multigenerational, case-control study. SETTING Nationwide multigeneration and patient registers in Sweden. PARTICIPANTS We conducted a study of in...
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ورودعنوان ژورنال:
- World psychiatry : official journal of the World Psychiatric Association
دوره 14 1 شماره
صفحات -
تاریخ انتشار 2015